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Article

Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria.

PloS one - 3 Oct 2007

Verra Federica, Simpore Jacques, Warimwe George M, Tetteh Kevin K, Howard Tevis, Osier Faith H A, Bancone Germana, Avellino Pamela, Blot Isa, Fegan Greg, Bull Peter C, Williams Thomas N, Conway David J, Marsh Kevin, Modiano David

Abstract excerpt

A recently proposed mechanism of protection for haemoglobin C (HbC; beta6Glu-->Lys) links an abnormal display of PfEMP1, an antigen involved in malaria pathogenesis, on the surface of HbC infected erythrocytes together with the observation of reduced cytoadhesion of parasitized erythrocytes and impaired rosetting in vitro. We investigated the impact of this hypothesis on the development of acquired immunity...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17912355
DOI: 10.1371/journal.pone.0000978
PMCID: PMC1991593

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Source receipt: pubmed, retrieved 7 Sept 2026.

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