Hemoglobin C Trait Provides Protection From Clinical Falciparum Malaria in Malian Children.

doi:10.1093/infdis/jiv308

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Article

Hemoglobin C Trait Provides Protection From Clinical Falciparum Malaria in Malian Children.

The Journal of infectious diseases - 1 Dec 2015

Travassos Mark A, Coulibaly Drissa, Laurens Matthew B, Dembélé Ahmadou, Tolo Youssouf, Koné Abdoulaye K, Traoré Karim, Niangaly Amadou, Guindo Aldiouma, Wu Yukun, Berry Andrea A, Jacob Christopher G, Takala-Harrison Shannon, Adams Matthew, Shrestha Biraj, Mu Amy Z, Kouriba Bourema, Lyke Kirsten E, Diallo Dapa A, Doumbo Ogobara K, Plowe Christopher V, Thera Mahamadou A

Abstract excerpt

BACKGROUND: Hemoglobin C trait, like hemoglobin S trait, protects against severe malaria in children, but it is unclear whether hemoglobin C trait also protects against uncomplicated malaria. We hypothesized that Malian children with hemoglobin C trait would have a lower risk of clinical malaria than children with hemoglobin AA. METHODS: Three hundred children aged 0-6 years were enrolled in a cohort study of...

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Identifiers

PMID: 26019283
DOI: 10.1093/infdis/jiv308
PMCID: PMC4633765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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