Article
Ex-vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C.
PloS one - 1 Jan 2014
Beaudry Jeanette T, Krause Michael A, Diakite Seidina A S, Fay Michael P, Joshi Gyan, Diakite Mahamadou, White Nicholas J, Fairhurst Rick M
Abstract excerpt
Sickle hemoglobin (Hb) S and HbC may protect against malaria by reducing the expression of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of parasitized red blood cells (RBCs), thereby weakening their cytoadherence to microvascular endothelial cells (MVECs) and impairing their activation of MVECs to produce pathological responses. Therefore, we hypothesized that parasites causing...
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