Article
Spontaneous mutation frequency and emergence of ciprofloxacin resistance in Campylobacter jejuni and Campylobacter coli.
The Journal of antimicrobial chemotherapy - 1 Dec 2007
Hänninen Marja-Liisa, Hannula Minna
Abstract excerpt
OBJECTIVES: We analysed the contribution of spontaneous mutation frequency to the evolution of ciprofloxacin resistance and the diversity of mutations in the quinolone resistance-determining region (QRDR) of gyrA and in the intergenic region, cmeR-cmeA, of the CmeABC efflux pump in Campylobacter jejuni and Campylobacter coli. METHODS: The mutation frequency was measured in 11 quinolone-susceptible C. jejuni and 5...
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