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Article

Mutation-based mechanism and evolution of the potent multidrug efflux pump RE-CmeABC in Campylobacter.

Proceedings of the National Academy of Sciences of the United States of America - 17 Dec 2024

Dai Lei, Wu Zuowei, Sahin Orhan, Zhao Shaohua, Yu Edward W, Zhang Qijing

Abstract excerpt

The resistance-nodulation-cell division (RND) superfamily of multidrug efflux systems are important players in mediating antibiotic resistance in gram-negative pathogens. Campylobacter jejuni, a major enteric pathogen, utilizes an RND-type transporter system, CmeABC, as the primary mechanism for extrusion of various antibiotics. Recently, a functionally potent variant of CmeABC (named RE-CmeABC) emerged in...

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Identifiers

PMID: 39602248
DOI: 10.1073/pnas.2415823121
PMCID: PMC11665921

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