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Article

In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pump.

Antimicrobial agents and chemotherapy - 1 Jan 2003

Luo Naidan, Sahin Orhan, Lin Jun, Michel Linda O, Zhang Qijing

Abstract excerpt

Enrofloxacin treatment of chickens infected with fluoroquinolone(FQ)-sensitive Campylobacter promoted the emergence of FQ-resistant Campylobacter mutants which propagated in the intestinal tract and recolonized the chickens. The recovered isolates were highly resistant to quinolone antibiotics but remained susceptible to non-FQ antimicrobial agents. Specific single-point mutations in the gyrA gene and the...

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Identifiers

PMID: 12499221
DOI: 10.1128/AAC.47.1.390-394.2003
PMCID: PMC148968

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