Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire.

The Journal of experimental medicine - 29 Oct 2007

Gray Daniel, Abramson Jakub, Benoist Christophe, Mathis Diane

Abstract excerpt

Expression of autoimmune regulator (Aire) by thymic medullary epithelial cells (MECs) is critical for central tolerance of self. To explore the mechanism by which such a rare cell population imposes tolerance on the large repertoire of differentiating thymocytes, we examined the proliferation and turnover of Aire(+) and Aire(-) MEC subsets through flow cytometric analysis of 5-bromo-2'deoxyuridine (BrdU)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIRE Protein
Share to Apoptosis
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Kinetics

Share to Mice, Knockout

Share to Mitosis

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 17908938
DOI: 10.1084/jem.20070795
PMCID: PMC2118482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire.PMID 17908938Read ↗

The role of Aire in clonal selectionSemantic proximity Read ↗

The Thymic Orchestration Involving Aire, miRNAs, and Cell–Cell Interactions during the Induction of Central ToleranceSemantic proximity Read ↗

Alterations of the Medullary Epithelial Compartment in the Aire-Deficient Thymus: Implications for Programs of Thymic Epithelial Differentiation,Semantic proximity Read ↗

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.Semantic proximity Read ↗

Deconstructing the Thymic Microenvironment Through Genesis to SenescenceSemantic proximity Read ↗

Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult ThymusSemantic proximity Read ↗

Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult ThymusSemantic proximity Read ↗

Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseasesSemantic proximity Read ↗

AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression*Semantic proximity Read ↗

Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cellsSemantic proximity Read ↗

Expression of Aire and the Early Wave of Apoptosis in SpermatogenesisSemantic proximity Read ↗

Ltbetar signaling does not regulate Aire-dependent transcripts in medullary thymic epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.