Back to search

Article

A genome-wide screen in macrophages identifies PTEN as required for myeloid restriction of <i>Listeria monocytogenes</i> infection

2022-12-12

Abstract excerpt

Listeria monocytogenes ( Lm ) is an intracellular foodborne pathogen which causes the severe disease listeriosis in immunocompromised individuals. Macrophages play a dual role during Lm infection by both promoting dissemination of Lm from the gastrointestinal tract and limiting bacterial growth upon immune activation. Despite the relevance of macrophages to Lm infection, the mechanisms underlying phagocytosis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
846f47ae-6f27-5edb-b122-32d6da8b38eb
DOI
10.1101/2022.12.12.520030
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A genome-wide screen in macrophages identifies PTEN as required for myeloid restriction of <i>Listeria monocytogenes</i> infectionDOI 10.1101/2022.12.12.520030
Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killingSemantic proximity
A genome-wide screen in <i>ex vivo</i> gallbladders identifies <i>Listeria monocytogenes</i> factors required for virulence <i>in vivo</i>Semantic proximity
RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spreadSemantic proximity
Recent advances in understanding Listeria monocytogenes infection: the importance of subcellular and physiological contextSemantic proximity
Listeria monocytogenes triggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy.Semantic proximity
Transcriptome responses of intestinal epithelial cells induced by membrane vesicles of <i>Listeria monocytogenes</i> unveil novel insights into the host-pathogen cross talkSemantic proximity
Dual Transcriptome Profiling of<i>Leishmania</i>-Infected Human Macrophages Reveals Distinct Reprogramming SignaturesSemantic proximity
Molecular determinants of Listeria monocytogenes virulence.Semantic proximity
Autophagy targeting of<i>Listeria monocytogenes</i>and the bacterial countermeasureSemantic proximity
Large-scale phenotyping and comparative genomics reveal genetic features of <i>Listeria</i> persistence in epithelial cellsSemantic proximity
Listeria monocytogenes evades killing by autophagy during colonization of host cells.Semantic proximity
Avoidance of Autophagy Mediated by PlcA or ActA Is Required for Listeria monocytogenes Growth in MacrophagesSemantic proximity
Select a neighboring publication to make it the new centre.