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Article

Listeria intracellular growth and virulence require host-derived lipoic acid.

Science (New York, N.Y.) - 17 Oct 2003

O'Riordan Mary, Moors Marlena A, Portnoy Daniel A

Abstract excerpt

Listeria monocytogenes is a Gram-positive intracytosolic pathogen that causes severe disease in pregnant and immunocompromised individuals. We found that L. monocytogenes lacking the lipoate protein ligase LplA1 was defective for growth specifically in the host cytosol and was less virulent in an...

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PMID: 14564012
DOI: 10.1126/science.1088170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14564012-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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