Article
Nonadherent cells switch to a Rac-mediated, SHIP regulated, Akt activation mode for survival.
Oncogene - 20 Mar 2008
Chaigne-Delalande B, Anies G, Kramer I, Genot E
Abstract excerpt
Constitutively active Rac stimulates Akt activity in T lymphocytes cultured in suspension. This regulation contrasts with findings obtained in fibroblasts, endothelial or neuronal cells grown on substrate, where Akt stimulation occurs independently of Rac. We now show that V12Rac-mediated stimulation of Akt is not restricted to the hematopoietic lineage but is dependent on the adherence status of the cell....
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