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Article

Scaffolding function of PAK in the PDK1-Akt pathway.

Nature cell biology - 1 Nov 2008

Higuchi Maiko, Onishi Keisuke, Kikuchi Chikako, Gotoh Yukiko

Abstract excerpt

Many extracellular signals stimulate phosphatidylinositol-3-kinase, which in turn activates the Rac1 GTPase, the protein kinase Akt and the Akt Thr 308 upstream kinase PDK1. Active Rac1 stimulates a number of events, including substrate phosphorylation by a subgroup of the PAK family of kinases. The combined effects of Rac1, PDK1 and Akt are crucial for cell migration, growth, survival, metabolism and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

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Source

Identifiers

PMID: 18931661
DOI: 10.1038/ncb1795

Genes

PDK1
PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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