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Article

AKT Signaling Prevailing in Mesenchymal Stromal Cells Modulates the Functionality of Hematopoietic Stem Cells via Intercellular Communication.

Stem cells (Dayton, Ohio) - 1 Sept 2016

Singh Shweta, Moirangthem Ranjita Devi, Vaidya Anuradha, Jalnapurkar Sapana, Limaye Lalita, Kale Vaijayanti

Abstract excerpt

The AKT pathway plays an important role in various aspects of stem cell biology. However, the consequences of constitutive activation of AKT in mesenchymal stromal cells (MSCs) on the fate of hematopoietic stem cells (HSCs) were unknown. Here, we show that bone marrow-derived MSCs expressing a constitutively active AKT1 expand HSCs, but severely affect their functionality. Conversely, stromal cells with silenced...

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Identifiers

PMID: 27300259
DOI: 10.1002/stem.2409

Genes

AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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