Article
Cyclin D1 A870G polymorphism in Brazilian colorectal cancer patients.
Journal of gastrointestinal cancer - 1 Jan 2008
Forones Nora Manoukian, de Lima Jacqueline Miranda, de Souza Lessileia Gomes, da Silva Ismael Dale Cotrim Guerreiro
Abstract excerpt
INTRODUCTION: Cyclin D1 (CCND1) is a regulatory protein involved in the cell cycle. A common G to A polymorphism in the CCND1 gene is implicated on the splicing of the CCND1 transcript, and this protein may be associated to a deregulated cell proliferation. AIM: Correlate the polymorphism A870G of CCND1 to the risk of colorectal cancer (CRC), to environmental risk factors and clinical aspects in Brazilian...
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