Article
Presence of valine at position 27 of the hepatitis B virus core gene is associated with severe liver inflammation in Chinese patients.
Journal of medical virology - 1 Feb 2011
Yang Ling, Ma Shiwu, Hu Xiaoxiong, Xiao Lei, Wang Zhanhui, Li Yongyin, Zhou Bin, Abbott William G H, Hou Jinlin
Abstract excerpt
Although it is widely believed that cytotoxic T lymphocytes (CTL) are responsible for severe flares of chronic hepatitis B that lead to liver failure, the published evidence to support this hypothesis is weak. The frequency of the I27V mutation in the HBV core gene, which produces a core 18-27 peptide capable of binding HLA-A*02, was compared in Chinese patients with severe liver inflammation (n = 77, including...
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