Article
Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2007
Zhang Donglu, Zhang Duxi, Cui Dan, Gambardella Janice, Ma Li, Barros Anthony, Wang Lifei, Fu Yunlin, Rahematpura Sandhya, Nielsen Julia, Donegan Michael, Zhang Hongjian, Humphreys W Griffith
Abstract excerpt
The UGT1A1*28 polymorphism is known to correlate with altered clearance of bilirubin (Gilbert syndrome) and drugs such as 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin (CPT-11). Although this polymorphism is clinically relevant and leads to significant drug-related toxicity of CPT-11, in vitro tools to allow prediction of how it will affect the clearance of new chemical entities have not...
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