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Article

Association analysis of UGT1A genotype and haplotype with SN-38 glucuronidation in human livers.

Pharmacogenomics - 1 Apr 2014

Wang Huijuan, Bian Ting, Jin Tianbo, Chen Yong, Lin Aifen, Chen Chao

Abstract excerpt

AIM: 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan, is mainly eliminated hepatically through glucuronidation by UGT1A1 and UGT1A9 enzymes. This study comprehensively investigates the effects of UGT1A1 and UGT1A9 genetic polymorphism on SN-38 glucuronidation activity. MATERIALS & METHODS: Genetic polymorphisms and combinational haplotypes of UGT1A1 and UGT1A9, SN-38 glucuronidation...

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Identifiers

PMID: 24897286
DOI: 10.2217/pgs.14.29

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