Article
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism.
Clinical pharmacology and therapeutics - 1 May 1999
Iyer L, Hall D, Das S, Mortell M A, Ramírez J, Kim S, Di Rienzo A, Ratain M J
Abstract excerpt
BACKGROUND: Hepatic uridine diphosphate glucuronosyltransferase (UGT) isoform 1A1 (UGT1A1) is primarily responsible for the glucuronidation of SN-38 (7-ethyl-10-hydroxycamptothecin), the active metabolite of the anticancer agent irinotecan. UGT1A1, also catalyzing the glucuronidation of bilirubin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.