Article
The 14bp-deletion allele in the HLA-G gene confers susceptibility to the development of hepatocellular carcinoma in the Brazilian population.
Tissue antigens - 1 Jun 2013
Teixeira A C, Mendes-Junior C T, Souza F F, Marano L A, Deghaide N H S, Ferreira S C, Mente E D, Sankarankutty A K, Elias-Junior J, Castro-e-Silva O, Donadi E A, Martinelli A L C
Abstract excerpt
Human leukocyte antigen-G (HLA-G) is a nonclassical HLA class I molecule involved in tumor escape mechanisms. Considering that the HLA-G 14bp insertion/deletion polymorphism is located at the 3' untranslated region (3'UTR) in exon 8, and since it has been associated with the magnitude of HLA-G production, we studied the association of 14bp insertion/deletion polymorphism with the risk of developing hepatocellular...
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