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Article

KRAS may facilitate transformation of chronic lymphocytic leukemia to histiocytic sarcoma with indeterminate dendritic cell features.

American journal of clinical pathology - 26 Aug 2025

Hassan Farhan, Zhang Hailing, Idiaquez Dietrich Werner, Pakasticali Nagehan, Hyjek Elizabeth, Hussaini Mohammad

Abstract excerpt

OBJECTIVE: We sought to investigate the molecular mechanism underlying transformation of chronic lymphocytic leukemia (CLL) to histiocytic sarcoma (HS) with indeterminate dendritic cell (IDC) features. METHODS: Extensive NGS-based genomic profiling was performed on samples of a patient who had CLL, secondary HS with IDC features, and CMML. Clonotypic evaluation of VDJ rearrangement status was performed to confirm...

Topics

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Aged
Biomarkers, Tumor
Cell Transformation, Neoplastic
Dendritic Cells
SF3B1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Lymphocytic, Chronic, B-Cell

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 40418704
DOI: 10.1093/ajcp/aqaf041

Genes

KRAS
BRAF
BCL2
BCL6
CD163
CD33
CD4
CD68
IGH
MPO
SF3B1
TCF4

Variants

Provenance

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