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Richter Transformation in Chronic Lymphocytic Leukemia: Update in the Era of Novel Agents

14 Oct 2021

Abstract excerpt

Richter transformation (RT) is a poorly understood complication of chronic lymphocytic leukemia (CLL) with a dismal prognosis. It is associated with a switch in histopathology and biology, generally with a transformation of the original CLL clone to diffuse large B-cell lymphoma (DLBCL) or less frequently to Hodgkin's variant of Richter transformation (HVRT). It occurs in 2-10% of CLL patients, with an incidence...

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PMID: 34680290
DOI: 10.3390/cancers13205141

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