Article
Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women.
Diabetic medicine : a journal of the British Diabetic Association - 1 Nov 2007
Qi L, van Dam R M, Asselbergs F W, Hu F B
Abstract excerpt
AIMS: Recent studies indicate transcription factor hepatocyte nuclear factor 4 alpha (HNF-4 alpha, HNF4A) modulates the transcription of the pancreatic B-cell ATP-sensitive K+ (KATP) channel subunit Kir6.2 gene (KCNJ11). Both HNF4A and KCNJ11 have previously been associated with diabetes risk but little is known whether the variations in these genes interact with each other. METHODS: We conducted a prospective,...
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