Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

doi:10.2337/db08-0719

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Article

Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

Diabetes - 1 Nov 2008

Barroso Inês, Luan Jian'an, Wheeler Eleanor, Whittaker Pamela, Wasson Jon, Zeggini Eleftheria, Weedon Michael N, Hunt Sarah, Venkatesh Ranganath, Frayling Timothy M, Delgado Marcos, Neuman Rosalind J, Zhao Jinghua, Sherva Richard, Glaser Benjamin, Walker Mark, Hitman Graham, McCarthy Mark I, Hattersley Andrew T, Permutt M Alan, Wareham Nicholas J, Deloukas Panagiotis

Abstract excerpt

OBJECTIVE: Single nucleotide polymorphisms (SNPs) in the P2 promoter region of HNF4A were originally shown to be associated with predisposition for type 2 diabetes in Finnish, Ashkenazi, and, more recently, Scandinavian populations, but they generated conflicting results in additional populations. We aimed to investigate whether data from a large-scale mapping approach would replicate this association in novel...

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PMID: 18728231
DOI: 10.2337/db08-0719
PMCID: PMC2570416

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Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.PMID 18728231Read ↗

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