Article
Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
Diabetes - 1 Nov 2004
Weedon Michael N, Owen Katharine R, Shields Beverley, Hitman Graham, Walker Mark, McCarthy Mark I, Love-Gregory Latisha D, Permutt M Alan, Hattersley Andrew T, Frayling Timothy M
Abstract excerpt
Hepatocyte nuclear factor (HNF)-4alpha is part of a transcription factor network that is key for the development and function of the beta-cell. Rare mutations in the HNF4alpha gene cause maturity-onset diabetes of the young. A number of type 2 diabetes linkage studies have found evidence of linkage to 20q12-13.1 where the HNF4alpha gene is located. Two recent studies have found an association between four common...
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