Article
Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.
The Journal of pathology - 1 Nov 2007
Jones A M, Thirlwell C, Howarth K M, Graham T, Chambers W, Segditsas S, Page K M, Phillips R K S, Thomas H J W, Sieber O M, Sawyer E J, Tomlinson I P M
Abstract excerpt
We have examined chromosomal-scale mutations in 34 large colorectal adenomas (CRAs). A small number of changes (median = 2, IQR = 0-4) were found by array-comparative genomic hybridization (aCGH) in most tumours. The most common changes were deletions of chromosomes 1p, 9q, 17, 19, and 22, and gains of chromosomes 13 and 21. SNP-LOH analysis and pseudo-digital SNP-PCR analysis detected occasional copy-neutral...
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