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Article

Family-based association test for time-to-onset data with time-dependent differences between the hazard functions.

Genetic epidemiology - 1 Feb 2006

Jiang Hongyu, Harrington David, Raby Benjamin A, Bertram Lars, Blacker Deborah, Weiss Scott T, Lange Christoph

Abstract excerpt

In genetic association studies, the differences between the hazard functions for the individual genotypes are often time-dependent. We address the non-proportional hazards data by using the weighted logrank approach by Fleming and Harrington [1981]:Commun Stat-Theor M 10:763-794. We introduce a weighted FBAT-Logrank whose weights are based on a non-parametric estimator for the genetic marker distribution function...

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PMID: 16374805
DOI: 10.1002/gepi.20132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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