Article
Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping.
American journal of human genetics - 1 Mar 2006
Wallace Chris, Chapman Juliet M, Clayton David G
Abstract excerpt
Selective genotyping is used to increase efficiency in genetic association studies of quantitative traits by genotyping only those individuals who deviate from the population mean. However, selection distorts the conditional distribution of the trait given genotype, and such data sets are usually...
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