Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Score tests for familial correlation in genotyped-proband designs.

Genetic epidemiology - 1 Apr 2000

Carroll R J, Gail M H, Benichou J, Pee D

Abstract excerpt

In the genotyped-proband design, a proband is selected based on an observed phenotype, the genotype of the proband is observed, and then the phenotypes of all first-degree relatives are obtained. The genotypes of these first-degree relatives are not observed. Gail et al. [(1999) Genet Epidemiol] discuss likelihood analysis of this design under the assumption that the phenotypes are conditionally independent of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Genes, BRCA1
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Likelihood Functions

Share to Models, Genetic

Share to Models, Statistical

Share to Penetrance

Share to Research Design

Source

Identifiers

PMID: 10797590
DOI: 10.1002/(SICI)1098-2272(200004)18:4<293::AID-GEPI3>3.0.CO;2-L

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Score tests for familial correlation in genotyped-proband designs.PMID 10797590Read ↗

Score statistic to test for genetic correlation for proband-family design.Semantic proximity Read ↗

Association score testing for rare variants and binary traits in family data with shared controls.Semantic proximity Read ↗

Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions.Semantic proximity Read ↗

Genetic association tests in family samples for multi-category phenotypesSemantic proximity Read ↗

Testing genetic association by regressing genotype over multiple phenotypes.Semantic proximity Read ↗

Approximate score-based testing with application to multivariate trait association analysis.Semantic proximity Read ↗

RL-SKAT: An Exact and Efficient Score Test for Heritability and Set Tests.Semantic proximity Read ↗

Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test.Semantic proximity Read ↗

Score tests for epistasis models on quantitative traits using general pedigree data.Semantic proximity Read ↗

Equivalence of three score tests for association mapping of quantitative trait loci under selective genotyping.Semantic proximity Read ↗

An exposure-weighted score test for genetic associations integrating environmental risk factors.Semantic proximity Read ↗

Genetic association tests for family data with missing parental genotypes: a comparison.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.