Article
A new statistic for the analysis of association between trait and polymorphic marker loci.
Mathematical biosciences - 1 Apr 2000
Choulakian V, Mahdi S
Abstract excerpt
Inference for detecting the existence of an association between a diallelic marker and a trait locus is based on the chi-squared statistic with one degree of freedom. For polymorphic markers with m alleles (2), three approaches are mainly used in practice. First, one may use Pearson's chi-squared statistic with m-1 degrees of freedom (d.f.) but this leads to a loss in test power. Second, one can select an allele...
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