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Article

The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells.

Biochemical and biophysical research communications - 23 Nov 2007

Mitsutake Susumu, Yokose Urara, Kato Mariko, Matsuoka Ichiro, Yoo Jae-Myung, Kim Tack-Joong, Yoo Hwan-Soo, Fujimoto Kazunori, Ando Yasuke, Sugiura Masako, Kohama Takafumi, Igarashi Yasuyuki

Abstract excerpt

The discovery of ceramide kinase (CerK), which phosphorylates ceramide (Cer) to ceramide 1-phisphate (C1P), established a new pathway for Cer metabolism. Among mouse tissues, brain contains the highest CerK activity. In this study, we found that CerK is highly expressed in cerebellar Purkinje cells. Since Purkinje cells are important for motor-related behaviors, we generated CerK-null mice and performed...

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Identifiers

PMID: 17888878
DOI: 10.1016/j.bbrc.2007.09.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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