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Article

Alterations in the testis of hormone sensitive lipase‐deficient mice is associated with decreased sperm counts, sperm motility, and fertility

20 Sept 2007

Abstract excerpt

Hormone-sensitive lipase (HSL, Lipe, E.C.3.1.1.3) functions as a triglyceride and cholesteryl esterase, supplying fatty acids, and cholesterol to cells. Gene-targeted HSL-deficient (HSL(-/-)) mice reveal abnormal spermatids and are infertile at 24 weeks after birth. The purpose of this study was to follow the evolution of spermatid abnormalities as HSL(-/-) mice age, characterize sperm motility in older HSL(-/-)...

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PMID: 17886267
DOI: 10.1002/mrd.20800

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