Article
The testicular form of hormone-sensitive lipase HSLtes confers rescue of male infertility in HSL-deficient mice.
The Journal of biological chemistry - 8 Oct 2004
Vallet-Erdtmann Virginie, Tavernier Geneviève, Contreras Juan Antonio, Mairal Aline, Rieu Cécile, Touzalin Anne-Marie, Holm Cecilia, Jégou Bernard, Langin Dominique
Abstract excerpt
Inactivation of the hormone-sensitive lipase gene (HSL) confers male sterility with a major defect in spermatogenesis. Several forms of HSL are expressed in testis. HSLtes mRNA and protein are found in early and elongated spermatids, respectively. The other forms are expressed in diploid germ cells and interstitial cells of the testis. To determine whether the absence of the testis-specific form of HSL, HSLtes,...
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