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Article

Reproductive pathology and sperm physiology in acid sphingomyelinase-deficient mice.

The American journal of pathology - 1 Sept 2002

Butler Avigdor, He Xingxuan, Gordon Ronald E, Wu Hai-Shan, Gatt Shimon, Schuchman Edward H

Abstract excerpt

Types A and B Niemann-Pick disease (NPD) are lysosomal storage disorders resulting from the deficient activity of acid sphingomyelinase (ASM). In this manuscript we report the pathobiology of male gonadal tissue and sperm in a knockout mouse model of NPD and demonstrate the importance of ASM for normal sperm maturation and function. Characteristic lipid-filled vacuoles were evident in light micrographs of testis'...

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Source

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Identifiers

PMID: 12213735
DOI: 10.1016/S0002-9440(10)64267-8
PMCID: PMC1867239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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