Article
Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
MacGregor G R, Russell L D, Van Beek M E, Hanten G R, Kovac M J, Kozak C A, Meistrich M L, Overbeek P A
Abstract excerpt
A line of transgenic mice that carries an insertional mutation in a gene essential for spermatogenesis is described. Males homozygous for the transgenic insert are sterile, while female homozygotes and both male and female heterozygotes exhibit normal fertility. Developing spermatids in homozygou...
Topics
- Alleles
- Animals
- Avian Sarcoma Viruses
- Cloning, Molecular
- DNA
- Female
- Genes, Recessive
- Genes, Viral
- Homozygote
- Male
- Mice
- Mice, Transgenic
- Mutation
- Pedigree
- Recombination, Genetic
- Restriction Mapping