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Article

Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation.

The Journal of physiology - 1 Nov 2007

Bianchi Matt T, Botzolakis Emmanuel J, Haas Kevin F, Fisher Janet L, Macdonald Robert L

Abstract excerpt

The time course of inhibitory postsynaptic currents (IPSCs) reflects GABA(A) receptor deactivation, the process of current relaxation following transient activation. Fast desensitization has been demonstrated to prolong deactivation, and these processes have been described as being 'coupled'. However, the relationship between desensitization and deactivation remains poorly understood. We investigated the...

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Identifiers

PMID: 17884921
DOI: 10.1113/jphysiol.2007.142364
PMCID: PMC2276985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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