Article
Genetic variation in the interleukin-10 gene promoter in Polish patients with systemic lupus erythematosus.
Rheumatology international - 1 Jun 2009
Sobkowiak Adam, Lianeri Margarita, Wudarski Mariusz, Łacki Jan K, Jagodziński Paweł P
Abstract excerpt
Identification of susceptibility genes in systemic lupus erythematosus (SLE) has recently become a topic of interest. The IL-10 promoter contains three single base-pair substitutions at -627C > A, -854C > T and -1117G > A. These single base-pair substitutions produce three different haplotypes, GCC, ACC and ATA, which affect IL-10 expression. We examined the distribution of -627C > A, -854C > T and -1117G > A...
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