Article
Analysis of transforming growth factor beta1 gene polymorphisms in patients with systemic sclerosis.
Annals of the rheumatic diseases - 1 Aug 2002
Crilly A, Hamilton J, Clark C J, Jardine A, Madhok R
Abstract excerpt
OBJECTIVES: To determine the distribution of transforming growth factor beta1 (TGFbeta1) genotypes at codon 10 (+869 polymorphism) and codon 25 (+915 polymorphism) in patients with scleroderma (SSc). Differences between diffuse and limited SSc (dSSc and lSSc) were also investigated. METHODS: Patients with lSSc (n=89) and dSSc (n=63) were compared with 147 controls. DNA was isolated from peripheral blood and...
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