Article
The -670G>A polymorphism in the FAS gene promoter region influences the susceptibility to systemic sclerosis.
Annals of the rheumatic diseases - 1 Apr 2009
Liakouli V, Manetti M, Pacini A, Tolusso B, Fatini C, Toscano A, Cipriani P, Guiducci S, Bazzichi L, Codullo V, Ruocco L, Dell'orso L, Carubbi F, Marrelli A, Abbate R, Bombardieri S, Ferraccioli G, Montecucco C, Valentini G, Matucci-Cerinic M, Ibba-Manneschi L, Giacomelli R
Abstract excerpt
OBJECTIVE: To evaluate the role of the single-nucleotide polymorphism (SNP) at position -670 in the FAS gene promoter (FAS-670G>A) in influencing the susceptibility, clinical features and severity of systemic sclerosis (SSc). METHODS: 350 white Italian SSc patients (259 with limited cutaneous SSc (lcSSc) and 91 with diffuse cutaneous SSc (dcSSc)) and 232 healthy individuals were studied. Patients were assessed...
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