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Article

The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.

Molecular and cellular biology - 1 Mar 2005

Cardone Monica, Kandilci Ayten, Carella Cintia, Nilsson Jonas A, Brennan Jennifer A, Sirma Sema, Ozbek Ugur, Boyd Kelli, Cleveland John L, Grosveld Gerard C

Abstract excerpt

The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc...

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Topics

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Share to Apoptosis
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Burkitt Lymphoma

Share to Proto-Oncogene Proteins c-ets

Share to Proto-Oncogene Proteins c-myc

Share to Suppression, Genetic

Share to Tumor Suppressor Protein p53

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 15743832
DOI: 10.1128/MCB.25.6.2395-2405.2005
PMCID: PMC1061619

Genes

MYC
ETV6
ETV7
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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