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Article

E2F2 suppresses Myc‐induced proliferation and tumorigenesis

1 Oct 2009

Abstract excerpt

Deregulation of E2F transcriptional activity as a result of alterations in the p16-cyclin D-Rb pathway is a hallmark of cancer. However, the roles of the different E2F family members in the process of tumorigenesis are still being elucidated. Studies in mice and humans suggest that E2F2 functions as a tumor suppressor. Here we demonstrate that E2f2 inactivation cooperates with transgenic expression of Myc to...

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PMID: 19798698
DOI: 10.1002/mc.20584

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