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Article

Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context

1 Nov 2006

Abstract excerpt

Deregulation of E2F transcriptional activity as a result of alterations in the p16(INK4a)-cyclin D1-Rb pathway is a hallmark of human cancer. E2F is a family of related factors that controls the expression of genes important for cell cycle progression as well as other processes such as apoptosis, DNA repair, and differentiation. Some E2F family members are associated with the activation of transcription and the...

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PMID: 17100599
DOI: 10.2174/1566524010606070731

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