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Article

7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G.

Journal of virology - 1 Dec 2007

Wang Tao, Tian Chunjuan, Zhang Wenyan, Luo Kun, Sarkis Phuong Thi Nguyen, Yu Lillian, Liu Bindong, Yu Yunkai, Yu Xiao-Fang

Abstract excerpt

Cytidine deaminase APOBEC3G (A3G) has broad antiviral activity against diverse retroviruses and/or retrotransposons, and its antiviral functions are believed to rely on its encapsidation into virions in an RNA-dependent fashion. However, the cofactors of A3G virion packaging have not yet been identified. We demonstrate here that A3G selectively interacts with certain polymerase III (Pol III)-derived RNAs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17881443
DOI: 10.1128/JVI.00892-07
PMCID: PMC2169093

Genes

SRP19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G.PMID 17881443Read ↗

Interaction with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging.Semantic proximity Read ↗

Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particlesSemantic proximity Read ↗

Association of Potent Human Antiviral Cytidine Deaminases with 7SL RNA and Viral RNP in HIV-1 VirionsSemantic proximity Read ↗

Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein ComplexesSemantic proximity Read ↗

Promiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1Semantic proximity Read ↗

Characterization of APOBEC3G binding to 7SL RNA.Semantic proximity Read ↗

GANP interacts with APOBEC3G and facilitates its encapsidation into the virions to reduce HIV-1 infectivity.Semantic proximity Read ↗

Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities.Semantic proximity Read ↗

Amino-Terminal Region of the Human Immunodeficiency Virus Type 1 Nucleocapsid Is Required for Human APOBEC3G PackagingSemantic proximity Read ↗

The Cellular Antiviral Protein APOBEC3G Interacts with HIV-1 Reverse Transcriptase and Inhibits Its Function during Viral ReplicationSemantic proximity Read ↗

cis-Acting determinants of 7SL RNA packaging by HIV-1.Semantic proximity Read ↗

Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 FamilySemantic proximity Read ↗

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