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Article

GANP interacts with APOBEC3G and facilitates its encapsidation into the virions to reduce HIV-1 infectivity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2013

Maeda Kazuhiko, Almofty Sarah Ameen, Singh Shailendra Kumar, Eid Mohammed Mansour Abbas, Shimoda Mayuko, Ikeda Terumasa, Koito Atsushi, Pham Phuong, Goodman Myron F, Sakaguchi Nobuo

Abstract excerpt

The ssDNA-dependent deoxycytidine deaminase apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G (A3G) is a potent restrictive factor against HIV-1 virus lacking viral-encoded infectivity factor (Vif) in CD4(+) T cells. A3G antiretroviral activity requires its encapsulation into HIV-1 virions. In this study, we show that germinal center-associated nuclear protein (GANP) is induced in activated...

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Identifiers

PMID: 24198285
DOI: 10.4049/jimmunol.1302057
PMCID: PMC4086635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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