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Article

Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles

24 Oct 2007

Abstract excerpt

Diverse retroviruses have been shown to package host SRP (7SL) RNA. However, little is known about the viral determinants of 7SL RNA packaging. Here we demonstrate that 7SL RNA is more selectively packaged into HIV-1 virions than are other abundant Pol-III-transcribed RNAs, including Y RNAs, 7SK RNA, U6 snRNA and cellular mRNAs. The majority of the virion-packaged 7SL RNAs were associated with the viral core...

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PMID: 17959647
DOI: 10.1093/nar/gkm816

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