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Promiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1

15 Jan 2015

Abstract excerpt

The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are cell-encoded cytidine deaminases, some of which, such as APOBEC3G (A3G) and APOBEC3F (A3F), act as potent human immunodeficiency virus type-1 (HIV-1) restriction factors. These proteins require packaging into HIV-1 particles to exert their antiviral activities, but the molecular mechanism by which this occurs is...

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PMID: 25590131
DOI: 10.1371/journal.ppat.1004609

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Related research

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Research trail→

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Promiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1PMID 25590131Read ↗

7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G.Semantic proximity Read ↗

Interaction with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging.Semantic proximity Read ↗

Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein ComplexesSemantic proximity Read ↗

Amino-Terminal Region of the Human Immunodeficiency Virus Type 1 Nucleocapsid Is Required for Human APOBEC3G PackagingSemantic proximity Read ↗

APOBEC3G Incorporation into Human Immunodeficiency Virus Type 1 ParticlesSemantic proximity Read ↗

Characterization of APOBEC3G binding to 7SL RNA.Semantic proximity Read ↗

RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.Semantic proximity Read ↗

Mechanism of Enhanced HIV Restriction by Virion Coencapsidated Cytidine Deaminases APOBEC3F and APOBEC3GSemantic proximity Read ↗

Encapsidation of APOBEC3G into HIV-1 virions involves lipid raft association and does not correlate with APOBEC3G oligomerizationSemantic proximity Read ↗

Human Apolipoprotein B mRNA-editing Enzyme-catalytic Polypeptide-like 3G (APOBEC3G) Is Incorporated into HIV-1 Virions through Interactions with Viral and Nonviral RNAsSemantic proximity Read ↗

The Cellular Antiviral Protein APOBEC3G Interacts with HIV-1 Reverse Transcriptase and Inhibits Its Function during Viral ReplicationSemantic proximity Read ↗

APOBEC3C tandem domain proteins create super restriction factors against HIV-1Semantic proximity Read ↗

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