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Article

Autoreactive T and B cells from bullous pemphigoid (BP) patients recognize epitopes clustered in distinct regions of BP180 and BP230.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2006

Thoma-Uszynski Sybille, Uter Wolfgang, Schwietzke Susanne, Schuler Gerold, Borradori Luca, Hertl Michael

Abstract excerpt

Bullous pemphigoid (BP) is a well-characterized model of autoantibody-mediated autoimmunity, which presumably depends on autoreactive Th cells that promote the activation of autoreactive B cells. The two major autoantigens of BP are BP180 and BP230, two components of dermoepidermal adhesion complexes. Both, autoreactive Th cell responses and autoantibody profiles were characterized in 35 patients with acute onset...

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Share to Autoantigens
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16424234
DOI: 10.4049/jimmunol.176.3.2015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autoreactive T and B cells from bullous pemphigoid (BP) patients recognize epitopes clustered in distinct regions of BP180 and BP230.PMID 16424234Read ↗

Clinical and immunological profiles of anti-BP230-type bullous pemphigoid: Restriction of epitopes to the C-terminal domain of BP230, shown by novel ELISAs of BP230-domain specific recombinant proteinsSemantic proximity Read ↗

Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain.Semantic proximity Read ↗

Characterization of the anti-BP180 autoantibody reactivity profile and epitope mapping in bullous pemphigoid patients.Semantic proximity Read ↗

Cloning and Primary Structural Analysis of the Bullous Pemphigoid Autoantigen BP180Semantic proximity Read ↗

Detection of IgE autoantibodies to BP180 and BP230 and their relationship to clinical features in bullous pemphigoid.Semantic proximity Read ↗

IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review.Semantic proximity Read ↗

Bullous pemphigoid antigen II (BP180) and its soluble extracellular domains are major autoantigens in mucous membrane pemphigoid: the pathogenic relevance to HLA class II alleles and disease severity.Semantic proximity Read ↗

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