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Article

Deletion of the major bullous pemphigoid epitope region of collagen XVII induces blistering, autoimmunization, and itching in mice.

The Journal of investigative dermatology - 1 May 2015

Hurskainen Tiina, Kokkonen Nina, Sormunen Raija, Jackow Joanna, Löffek Stefanie, Soininen Raija, Franzke Claus-Werner, Bruckner-Tuderman Leena, Tasanen Kaisa

Abstract excerpt

Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease with a characteristic of pruritus and blistering. BP patients carry inflammation-triggering autoantibodies against the collagen XVII (ColXVII, also known as BP180) juxtamembraneous extracellular noncollagenous 16A (NC16A) domain involved in ectodomain shedding. Deletion of the corresponding NC14A region in a genetically...

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PMID: 25310407
DOI: 10.1038/jid.2014.443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion of the major bullous pemphigoid epitope region of collagen XVII induces blistering, autoimmunization, and itching in mice.PMID 25310407Read ↗

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