Article
Interleukin 8 and cell migration to inflammatory sites: the regulation of focal adhesion kinase under conditions of migratory desensitization.
The Israel Medical Association journal : IMAJ - 1 Aug 2007
Cohen-Hillel Efrat, Yron Ilana, Meshel Tsipi, Ben-Baruch Adit
Abstract excerpt
BACKGROUND: Interleukin 8 is a prototypical inflammatory chemokine that induces leukocyte migration to inflammatory sites. Leukocyte recruitment in response to gradients of this chemokine is attenuated at advanced stages of inflammation to prevent damage to surrounding healthy tissues. Our published studies suggest that over-phosphorylation of focal adhesion kinase in migration-desensitizing conditions is...
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