Article
Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2001
Hannigan M O, Zhan L, Ai Y, Kotlyarov A, Gaestel M, Huang C K
Abstract excerpt
Time-lapsed video microscopy and confocal imaging were used to study the migration of wild-type (WT) and mitogen-activated protein kinase-activated protein kinase 2 (MK2-/-) mouse neutrophils in Zigmond chambers containing fMLP gradients. Confocal images of polarized WT neutrophils showed an intracellular gradient of phospho-MK2 from the anterior to the posterior region of the neutrophils. Compared with WT...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.