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Article

Functional architecture and evolution of transcriptional elements that drive gene coexpression.

Science (New York, N.Y.) - 14 Sept 2007

Brown Christopher D, Johnson David S, Sidow Arend

Abstract excerpt

Transcriptional coexpression of interacting gene products is required for complex molecular processes; however, the function and evolution of cis-regulatory elements that orchestrate coexpression remain largely unexplored. We mutagenized 19 regulatory elements that drive coexpression of Ciona muscle genes and obtained quantitative estimates of the cis-regulatory activity of the 77 motifs that comprise these...

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Identifiers

PMID: 17872446
DOI: 10.1126/science.1145893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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