Article
An evolutionary constraint: strongly disfavored class of change in DNA sequence during divergence of cis-regulatory modules.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005
Cameron R Andrew, Chow Suk Hen, Berney Kevin, Chiu Tsz-Yeung, Yuan Qiu-Autumn, Krämer Alexander, Helguero Argelia, Ransick Andrew, Yun Mirong, Davidson Eric H
Abstract excerpt
The DNA of functional cis-regulatory modules displays extensive sequence conservation in comparisons of genomes from modestly distant species. Patches of sequence that are several hundred base pairs in length within these modules are often seen to be 80-95% identical, although the flanking sequence cannot even be aligned. However, it is unlikely that base pairs located between the transcription factor target...
Topics
- Animals
- Base Sequence
- DNA
- Evolution, Molecular
- Models, Genetic
- Molecular Sequence Data
- Polymorphism, Single Nucleotide
- Regulatory Sequences, Nucleic Acid
- Sea Urchins